Each Kleenex Anti-Viral tissue has three soft layers, including a moisture-activated middle layer that kills 99.9% of cold & flu viruses in the tissue within 15 minutes. It's virucidal against Rhinoviruses Type 1A & 2 (rhinoviruses are the leading cause of the common cold), Influenza A & B (causes of the flu), Respiratory Syncytial Virus (RSVthe leading cause of lower respiratory infection in children). Each box comes with tissues that feature small blue dots on the interior layer, which signal they're anti-viral. Buy in bulk, so you won't run out! 3-Box Shrink Wrapped. Tissue Type: Facial; Number of Plies: 3; Number of Sheets: 60 / Box; Length: 8.2".